The Role of Sports and Antidiabetic Drugs in Managing T2DM

Oct 13, 2025 by windailys.com 121 views

The Effect of Slow Type Training Combination and Ethanol Extract of Ant Nest (Myrmecodia Pendanan) on Superoxide Dismutase Expressions, P-Selectin Levels and Number of Foam Cells in Type-2 Diabetes Mellitus Wistar Model Rice

Understanding the Complications of Type-2 Diabetes Mellitus

Type-2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired insulin secretion. Macrovascular complications are the main cause of death in patients with T2DM, accounting for approximately 80% of all deaths. The increased free radicals due to hyperglycemia trigger endothelial dysfunction, characterized by an increase in cellular adhesion molecules such as p-selectin. This condition causes LDL cholesterol to be oxidized (OxLDL) diffagocytosis by macrophages, forming foam cells. This foam cell is an early marker of atherosclerotic lesions.

The Role of Sports and Antidiabetic Drugs in Managing T2DM

Sports and antidiabetic drugs are an integral part of T2DM handling. Interval training, especially the slow type, is often chosen by T2DM patients. Ant nest plants (Myrmecodia pendans) are believed to have the potential for antidiabetic and antioxidants that benefit T2DM patients. The combination of slow type training interval and ethanol extract of ant nest may provide a new solution to overcome the complications of T2DM.

The Study Aim and Methodology

This study aims to analyze the effect of a combination of slow type of training interval and ethanol ant nest extract on the expression of superoxide dismutase (SOD), P-Selectin levels, and the number of foam cells in the Wistar Rice Type-2 Diabetes Melitus (T2DM). The study used 25 male wistar mice induced into a T2DM model with a high fat diet and low dose streptozotocin injection. The rats were divided into 4 groups: K1 (T2DM), K2 (T2DM + Slow type interval training), K3 (T2DM + Ant Nest Ethanol Extract), and K4 (T2DM + Slow Type Training Interval Combination and Ethanol Ant Nest Extract). Slow type training interval was done by running on a treadmill, and ethanol extract of ant nests was given at a dose of 400mg/kg BW for 8 weeks.

The Results of the Study

Anova test shows a significant difference in SOD's expression between the four groups. The post HOC test shows the highest SOD expression is found in K4 (4.18 ± 0.41), significantly different from K2 (3.38 ± 0.87) and K1 (2.41 ± 0.31) (p <0.05), but no significant different from K3 (3.67 ± 0.57) (P> 0.05). The lowest P-Selectin levels are found in K4 [(2,61 (1,15-6.50)], significantly different from K1 [6.77 (3.88-31.51)] (p <0.05). The number of foam cells is also significantly reduced in K4 compared to K1 and K3.

The Conclusion of the Study

Additional Analysis and Explanation

Increased SOD expression plays an important role in counteracting free radicals, protecting endothelial cells from damage, and reducing the risk of endothelial dysfunction. A decrease in the number of foam cells shows the effectiveness of this therapy combination in inhibiting the formation of atherosclerotic plaque, so as to prevent heart attacks and strokes. However, this research is still in the early stages and needs to be further studied on a larger scale and by involving humans.

Suggestion for Further Research

Further research is needed to understand the mechanism of work combination of this therapy, optimal doses, and its effect on other health parameters in DM patients. In addition, clinical studies in humans need to be done to validate the results of this study and ensure their safety.

The Potential of Ant Nest Extract in Managing T2DM

Ant nest plants (Myrmecodia pendans) have been traditionally used in Southeast Asia for their medicinal properties. The ethanol extract of ant nest has been shown to have antidiabetic and antioxidant properties, which may be beneficial in managing T2DM. The combination of slow type training interval and ethanol extract of ant nest may provide a new solution to overcome the complications of T2DM.

The Importance of SOD Expression in Managing T2DM

Superoxide dismutase (SOD) is an antioxidant enzyme that plays a crucial role in counteracting free radicals. Increased SOD expression has been shown to reduce the risk of endothelial dysfunction and atherosclerotic plaque formation. The combination of slow type training interval and ethanol extract of ant nest may increase SOD expression, which may be beneficial in managing T2DM.

The Role of P-Selectin in Managing T2DM

P-selectin is a cellular adhesion molecule that plays a crucial role in the formation of atherosclerotic plaque. Increased P-selectin levels have been shown to be associated with endothelial dysfunction and atherosclerosis. The combination of slow type training interval and ethanol extract of ant nest may reduce P-selectin levels, which may be beneficial in managing T2DM.

The Potential of Slow Type Training Interval in Managing T2DM

Slow type training interval has been shown to be beneficial in managing T2DM. The combination of slow type training interval and ethanol extract of ant nest may provide a new solution to overcome the complications of T2DM. Further research is needed to understand the mechanism of work combination of this therapy and its effect on other health parameters in DM patients.

Conclusion

The combination of slow type of training interval and ethanol extract of ant nest nests is more effective in increasing the expression of SOD antioxidant enzymes and reducing the number of foam cells in the T2DM model of wistar strain mice. This finding shows the great potential of this therapy combination in controlling macrovascular complications in DM patients. Further research is needed to understand the mechanism of work combination of this therapy, optimal doses, and its effect on other health parameters in DM patients.
Q&A: The Effect of Slow Type Training Combination and Ethanol Extract of Ant Nest on Superoxide Dismutase Expressions, P-Selectin Levels and Number of Foam Cells in Type-2 Diabetes Mellitus Wistar Model Rice

Q: What is the main goal of this study?

A: The main goal of this study is to analyze the effect of a combination of slow type of training interval and ethanol ant nest extract on the expression of superoxide dismutase (SOD), P-Selectin levels, and the number of foam cells in the Wistar Rice Type-2 Diabetes Melitus (T2DM).

Q: What is the significance of this study?

A: This study is significant because it provides new insights into the potential of slow type training interval and ethanol extract of ant nest in managing T2DM. The combination of these two interventions may provide a new solution to overcome the complications of T2DM.

Q: What are the potential benefits of slow type training interval in managing T2DM?

A: Slow type training interval has been shown to be beneficial in managing T2DM. The potential benefits of slow type training interval include increased SOD expression, reduced P-selectin levels, and reduced number of foam cells.

Q: What are the potential benefits of ethanol extract of ant nest in managing T2DM?

A: Ethanol extract of ant nest has been shown to have antidiabetic and antioxidant properties, which may be beneficial in managing T2DM. The potential benefits of ethanol extract of ant nest include increased SOD expression, reduced P-selectin levels, and reduced number of foam cells.

Q: How does the combination of slow type training interval and ethanol extract of ant nest work?

A: The combination of slow type training interval and ethanol extract of ant nest may work by increasing SOD expression, reducing P-selectin levels, and reducing the number of foam cells. This may help to prevent endothelial dysfunction and atherosclerotic plaque formation.

Q: What are the potential risks and side effects of this therapy combination?

A: The potential risks and side effects of this therapy combination are not well understood and require further research. However, it is essential to note that this research is still in the early stages and needs to be further studied on a larger scale and by involving humans.

Q: How can this therapy combination be used in clinical practice?

A: This therapy combination may be used in clinical practice to manage T2DM. However, further research is needed to understand the optimal doses, mechanism of action, and potential risks and side effects of this therapy combination.

Q: What are the next steps for this research?

A: The next steps for this research include further studies on the mechanism of action of this therapy combination, optimal doses, and potential risks and side effects. Additionally, clinical studies in humans need to be done to validate the results of this study and ensure their safety.

Q: What are the implications of this research for patients with T2DM?

A: This research has significant implications for patients with T2DM. The combination of slow type training interval and ethanol extract of ant nest may provide a new solution to overcome the complications of T2DM. However, further research is needed to understand the optimal doses, mechanism of action, and potential risks and side effects of this therapy combination.

Q: What are the implications of this research for healthcare professionals?

A: This research has significant implications for healthcare professionals. The combination of slow type training interval and ethanol extract of ant nest may be a new treatment option for patients with T2DM. However, further research is needed to understand the optimal doses, mechanism of action, and potential risks and side effects of this therapy combination.

Q: What are the future directions for this research?

A: The future directions for this research include further studies on the mechanism of action of this therapy combination, optimal doses, and potential risks and side effects. Additionally, clinical studies in humans need to be done to validate the results of this study and ensure their safety.