The Relationship Between Nitric Oxide Levels and the Number of Absolute Neutrophils with Outcomes in Acute Ischemic Stroke Patients

Oct 13, 2025 by windailys.com 8 views

The Relationship Between Nitric Oxide Levels and the Number of Absolute Neutrophils with Outcomes in Acute Ischemic Stroke Patients

Acute ischemic stroke is a medical emergency that requires prompt and effective treatment to minimize damage to the brain and improve patient outcomes. Recent studies have highlighted the importance of understanding the underlying mechanisms of ischemic stroke, including the role of nitric oxide (NO) and the number of absolute neutrophils. NO is a molecule that plays a crucial role in various biological processes, including in the brain, where it acts as a neuroprotector and neurotoxin. The number of absolute neutrophils, on the other hand, is a marker of inflammation and has been shown to be associated with poor outcomes in stroke patients. This study aims to explore the relationship between nitric oxide levels and the number of absolute neutrophils with clinical outcomes in acute ischemic stroke patients.

Nitric oxide (NO) is a molecule that has an important role in various biological processes, including in the brain. NO acts as a neuroprotector, protecting nerve cells from damage, but it can also be neurotoxic in the condition of the brain ischemia. The role of NO in ischemic stroke is complex and multifaceted, and its levels have been shown to be altered in patients with acute ischemic stroke. On the other hand, the number of absolute neutrophils is a marker of inflammation and has been shown to be associated with poor outcomes in stroke patients. An increase in the number of leukocytes, including neutrophils, is a common finding in patients with acute ischemic stroke, and it can be a bad indicator of their clinical results.

This study was conducted in a longitudinal prospective design from June to October 2017. A total of 21 patients with acute ischemic stroke were recruited for the study, and samples were taken three times, namely on the first, third, and seventh day. Nitric oxide levels were measured using a Chemwell Analyzer, while the number of absolute neutrophils was measured using a Sysmex XN-1000. The study aimed to explore the relationship between nitric oxide levels and the number of absolute neutrophils with clinical outcomes in acute ischemic stroke patients.

The results of the study showed that the number of absolute neutrophils was significantly higher on the first, third, and seventh day compared to the baseline values (p = 0.001). However, there was no significant difference in nitric oxide levels on the same day (p = 0.716). The Spearman correlation test showed a significant relationship between the number of absolute neutrophils and the outcome results in the acute ischemic stroke (p = 0.001). However, there was no significant relationship between nitric oxide levels and patient outcomes (P> 0.05). This finding highlights the importance of the number of neutrophils as a prognostic parameter in acute ischemic stroke patients.

Based on the results of the study, the number of absolute neutrophils can be a valuable predictor for determining the results of patients with acute ischemic stroke. Therefore, it is highly recommended that clinicians pay attention to the number of absolute neutrophils when treating stroke patients, because this can be used as an effective prognosis. In addition, it is recommended to examine more specific nitric oxide levels, such as Enos, NNOS, and Inos, in order to get a clearer picture of the role of NO in the pathophysiology of ischemic stroke. Through this research, it is expected to contribute to clinical practices and further research on the management of acute ischemic stroke patients, and make attention to the number of absolute neutrophils as part of the holistic approach in handling these patients.

This study has several limitations, including the small sample size and the lack of control group. Future studies should aim to recruit a larger sample size and include a control group to increase the generalizability of the findings. Additionally, further research is needed to explore the role of nitric oxide in the pathophysiology of ischemic stroke and to develop more effective treatments for stroke patients.

In conclusion, this study highlights the importance of the number of absolute neutrophils as a prognostic parameter in acute ischemic stroke patients. The results of the study suggest that clinicians should pay attention to the number of absolute neutrophils when treating stroke patients, and that further research is needed to explore the role of nitric oxide in the pathophysiology of ischemic stroke. Through this research, it is expected to contribute to clinical practices and further research on the management of acute ischemic stroke patients.
Frequently Asked Questions (FAQs) About the Relationship Between Nitric Oxide Levels and the Number of Absolute Neutrophils with Outcomes in Acute Ischemic Stroke Patients

A: The study found that there was no significant relationship between nitric oxide levels and patient outcomes in acute ischemic stroke patients. However, there was a significant relationship between the number of absolute neutrophils and the outcome results in the acute ischemic stroke.

A: The number of absolute neutrophils is a marker of inflammation and has been shown to be associated with poor outcomes in stroke patients. An increase in the number of leukocytes, including neutrophils, is a common finding in patients with acute ischemic stroke, and it can be a bad indicator of their clinical results.

A: This study has several limitations, including the small sample size and the lack of control group. Future studies should aim to recruit a larger sample size and include a control group to increase the generalizability of the findings.

A: The study highlights the importance of the number of absolute neutrophils as a prognostic parameter in acute ischemic stroke patients. Clinicians should pay attention to the number of absolute neutrophils when treating stroke patients, as this can be used as an effective prognosis.

A: Further research is needed to explore the role of nitric oxide in the pathophysiology of ischemic stroke and to develop more effective treatments for stroke patients. Additionally, studies should aim to recruit a larger sample size and include a control group to increase the generalizability of the findings.

A: This research has the potential to contribute to clinical practices and further research on the management of acute ischemic stroke patients. It can also inform the development of more effective treatments for stroke patients and improve patient outcomes.

A: The potential risks of this research include the use of invasive procedures and the potential for adverse reactions to the medications used in the study. The potential benefits of this research include the development of more effective treatments for stroke patients and improved patient outcomes.

A: Readers can get involved in this research by participating in clinical trials, volunteering for research studies, or donating to organizations that support stroke research. They can also stay informed about the latest developments in stroke research and advocate for increased funding for stroke research.

A: The next steps for this research include recruiting a larger sample size, including a control group, and conducting further studies to explore the role of nitric oxide in the pathophysiology of ischemic stroke. Additionally, studies should aim to develop more effective treatments for stroke patients and improve patient outcomes.