The Potential of Giring Rhizome Extract in Burns Treatment

Oct 13, 2025 by windailys.com 68 views

The Healing Effect of Burns Hydrogel Preparation of the Rhizome Giring Extract (Curcuma Heyneana Valeton & Zipj) in Male White Mice

Burns are a type of injury that can have a significant impact on an individual's health and well-being. According to the World Health Organization (WHO), burns are a leading cause of morbidity and mortality worldwide. In addition to the physical pain and discomfort associated with burns, they can also lead to long-term health consequences, such as scarring, infection, and even death. Therefore, it is essential to develop effective treatments for burns that can accelerate the healing process and reduce the risk of complications.

The Potential of Giring Rhizome Extract in Burns Treatment

Giring rhizome (Curcuma Heyneana Valeton & ZIPJ) is a plant that has been used in traditional medicine for centuries due to its various health benefits, including anti-inflammatory, antibacterial, and antioxidant activity. Studies have shown that the extract of this plant has potential therapeutic effects on various diseases, including wounds and burns. This study aims to investigate the effects of hydrogel preparations based on ethanol extract of the rhizome Giring as an alternative treatment to accelerate the healing process of burns in male white mice.

Research Objectives

The primary objective of this study is to investigate the effects of hydrogel preparations of ethanol extract of the rhizome Giring on the healing of burns in male white mice. By understanding the effectiveness of this preparation in accelerating healing, it is expected to contribute to the development of better health products for the treatment of burns.

Methodology

The research process begins with the manufacture of hydrogel preparations from ethanol extract of the rhizome Giring with a variation of 5%, 10%, and 20% concentration variations. This manufacture uses a carbopol base 940, which is a common base used in the production of hydrogel preparations. To test the healing effect, burns are induced using hot metal, which is heated at 100 ° C for 15 minutes and attached to the back of the rat for 5 seconds. After the treatment, the wound area was observed regularly, and histopathological analysis was carried out to assess the healing level.

Research Results

The results showed that the hydrogel preparation of the ethanol extract of the Giring rhizome had a positive effect in healing burns. There is a significant difference (p <0.1) between groups that are given hydrogel and control groups that use ordinary hydrogel bases. From the analysis conducted, hydrogel with a concentration of 5% shows the highest Under Curve (AUC) area value of 150.33 ± 105.18, indicates that this preparation is most effective in accelerating wound healing.

Conclusion

From the results of this study, it can be concluded that the hydrogel preparation of ethanol extract of the rhizome Giring has the potential to be an effective solution for healing burns. Especially, hydrogel with a concentration of 5% shows the best results in accelerating the wound healing process. This discovery opens opportunities for further development in burns therapy, which can bring significant benefits in medical practice and public health.

Benefits for Readers

By understanding the effectiveness of the hydrogel in healing burns, the reader can assess the potential for the use of natural ingredients in healthcare. In addition, this article can provide important information for researchers and medical practitioners about alternative treatment of wounds that may be safer and more effective compared to conventional drugs. Considering that the Giring rhizome is a natural ingredient, the use of hydrogel preparations also has the potential to reduce the side effects that are often caused by chemical drugs.

Through this research, it is expected to encourage further research in the use of other natural ingredients as a wound healing agent, as well as increasing awareness of the importance of research and development in the field of herbal-based health.

Future Directions

This study provides a foundation for further research in the use of hydrogel preparations based on ethanol extract of the rhizome Giring as a treatment for burns. Future studies can investigate the effects of different concentrations of the extract on wound healing, as well as the potential of this preparation in combination with other natural ingredients. Additionally, the study can be replicated in humans to assess the safety and efficacy of this treatment in a clinical setting.

Conclusion

In conclusion, this study demonstrates the potential of hydrogel preparations based on ethanol extract of the rhizome Giring as a treatment for burns. The results of this study provide a foundation for further research in the use of natural ingredients as a wound healing agent, and highlight the importance of research and development in the field of herbal-based health.
Q&A: The Healing Effect of Burns Hydrogel Preparation of the Rhizome Giring Extract (Curcuma Heyneana Valeton & Zipj) in Male White Mice

In our previous article, we discussed the potential of hydrogel preparations based on ethanol extract of the rhizome Giring as a treatment for burns. This study aims to investigate the effects of hydrogel preparations of ethanol extract of the rhizome Giring on the healing of burns in male white mice. In this Q&A article, we will answer some of the most frequently asked questions about this study.

Q: What is the purpose of this study?

A: The primary objective of this study is to investigate the effects of hydrogel preparations of ethanol extract of the rhizome Giring on the healing of burns in male white mice. By understanding the effectiveness of this preparation in accelerating healing, it is expected to contribute to the development of better health products for the treatment of burns.

Q: What is the method used in this study?

A: The research process begins with the manufacture of hydrogel preparations from ethanol extract of the rhizome Giring with a variation of 5%, 10%, and 20% concentration variations. This manufacture uses a carbopol base 940, which is a common base used in the production of hydrogel preparations. To test the healing effect, burns are induced using hot metal, which is heated at 100 ° C for 15 minutes and attached to the back of the rat for 5 seconds. After the treatment, the wound area was observed regularly, and histopathological analysis was carried out to assess the healing level.

Q: What are the results of this study?

A: The results showed that the hydrogel preparation of the ethanol extract of the Giring rhizome had a positive effect in healing burns. There is a significant difference (p <0.1) between groups that are given hydrogel and control groups that use ordinary hydrogel bases. From the analysis conducted, hydrogel with a concentration of 5% shows the highest Under Curve (AUC) area value of 150.33 ± 105.18, indicates that this preparation is most effective in accelerating wound healing.

Q: What are the benefits of this study?

A: By understanding the effectiveness of the hydrogel in healing burns, the reader can assess the potential for the use of natural ingredients in healthcare. In addition, this article can provide important information for researchers and medical practitioners about alternative treatment of wounds that may be safer and more effective compared to conventional drugs. Considering that the Giring rhizome is a natural ingredient, the use of hydrogel preparations also has the potential to reduce the side effects that are often caused by chemical drugs.

Q: What are the future directions of this study?

A: This study provides a foundation for further research in the use of hydrogel preparations based on ethanol extract of the rhizome Giring as a treatment for burns. Future studies can investigate the effects of different concentrations of the extract on wound healing, as well as the potential of this preparation in combination with other natural ingredients. Additionally, the study can be replicated in humans to assess the safety and efficacy of this treatment in a clinical setting.

Q: What are the limitations of this study?

A: This study has some limitations, including the use of male white mice as the model organism and the limited number of concentration variations used. Future studies can address these limitations by using a more diverse range of model organisms and concentration variations.

Q: What are the implications of this study?

A: This study has significant implications for the development of new treatments for burns. The use of natural ingredients, such as the Giring rhizome, has the potential to reduce the side effects associated with conventional treatments and provide a safer and more effective alternative. Additionally, this study highlights the importance of research and development in the field of herbal-based health.

Q: What are the next steps in this research?

A: The next steps in this research will involve further investigation of the effects of hydrogel preparations based on ethanol extract of the rhizome Giring on wound healing. Future studies can investigate the effects of different concentrations of the extract on wound healing, as well as the potential of this preparation in combination with other natural ingredients. Additionally, the study can be replicated in humans to assess the safety and efficacy of this treatment in a clinical setting.