The Importance of Natural Dyes in Pharmaceuticals

Oct 13, 2025 by windailys.com 120 views

Making Vitamin C Tablets Using Turmeric Rhizome Extract (Curcuma Domestica Val.) As a Dye by the Basic Granulation Method

Introduction

In recent years, there has been a growing interest in the use of natural dyes in various industries, including pharmaceuticals. Natural dyes have been used since ancient times and are generally considered safer than synthetic dyes. Synthetic dyes often have a negative impact on health, and therefore, it is essential to explore alternative options. Turmeric rhizome extract (curcuma domestica val.) is a yellow natural dye that can be utilized in making vitamin C tablets. This article aims to explore the use of turmeric extract as a tablet coloring and determine the most preferred concentration.

The Importance of Natural Dyes in Pharmaceuticals

Natural dyes have been used in various industries, including textiles, food, and pharmaceuticals. In pharmaceuticals, natural dyes are used to color tablets, capsules, and other dosage forms. The use of natural dyes in pharmaceuticals has several advantages, including:

Safety: Natural dyes are generally considered safer than synthetic dyes, which can have a negative impact on health.
Attractiveness: Natural dyes can provide attractive colors, making pharmaceutical products more appealing to consumers.
Antioxidant properties: Many natural dyes, including turmeric extract, have antioxidant properties, which can provide additional health benefits.
Sustainability: The use of natural dyes can contribute to a more sustainable health industry.

Research Methods

This study uses the method of extraction of percolation with 96% ethanol solvent to obtain turmeric rhizome extract. Tablet manufacturing is done by the basic granulation method. The variation of the ascorbic acid dose (vitamin C) used is 50 mg for the F1-F3 formula with variations in coloring concentrations of 1%, 1.5%, and 2%. As for the F4-F6 formula, the dose of vitamin C used is 25 mg with the same dye concentration. The F7 formula uses 50 mg of vitamin C and tartrazine 0.03 mg as a comparison. The resulting tablets are then evaluated in terms of violence, friability, destroyed time, uniformity of the content, determination of levels, dissolution, and assessment by 20 panelists regarding color.

Research Results

The results showed that the water content of turmeric rhizomes obtained was 4.98%, with an extraction yield of 350 g of simplicia powder reaching 18.154%. Violence tests showed variations in violence from F1 to F7 ranging from 4,036 kg to 4,602 kg. The friability test shows the value between 0.34% to 0.55%, which shows tablet stability. Destroyed time varies between 7.07 to 8.03 minutes, and the uniformity of the womb is in the range of 99.7795% to 108.1260%. Determination of levels also shows consistent results, ranging from 97.536% to 104,1356%. Finally, the results of the hedonic test show that varying preference assessment, with F6 and F5 is considered "like" and "very like" by panelists.

Analysis and Discussion

From the results of the study, it can be concluded that turmeric rhizome extract can be used effectively as a coloring in making vitamin C tablets. 2% concentration for tablets containing 50 mg of vitamin C and 1.5% for tablets with 25 mg of vitamin C is the most preferred choice by panelists. This indicates that natural dyes can be a good alternative for synthetic dyes in pharmaceutical products.

The advantages of using natural dyes such as turmeric extract not only provide attractive colors, but also have the potential to bring additional health benefits given the antioxidant properties contained in turmeric. In addition, higher security than synthetic dyes provides added value for consumers who are increasingly aware of health.

Conclusion

This study shows that turmeric rhizome extract (curcuma domestica Val.) is a good choice as a vitamin C tablet coloring. The evaluation results show that the resulting tablet meets the expected quality standards. The use of natural dyes in pharmaceutical products can help increase product attractiveness and safety, as well as contribute to a more sustainable health industry.

Future Directions

This study provides a foundation for further research on the use of natural dyes in pharmaceuticals. Future studies can explore the use of other natural dyes, such as beetroot extract or annatto extract, as coloring agents in vitamin C tablets. Additionally, studies can investigate the potential health benefits of using natural dyes in pharmaceuticals.

References

[List of references cited in the study]

Appendix

[Appendix containing additional information, such as raw data or additional figures and tables]

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Frequently Asked Questions (FAQs) About Making Vitamin C Tablets Using Turmeric Rhizome Extract (Curcuma Domestica Val.)

Q: What is the purpose of using turmeric rhizome extract as a coloring agent in vitamin C tablets?

A: The purpose of using turmeric rhizome extract as a coloring agent in vitamin C tablets is to provide a natural and safe alternative to synthetic dyes. Turmeric extract has been shown to be effective in coloring tablets and has potential health benefits due to its antioxidant properties.

Q: What are the advantages of using natural dyes like turmeric extract in pharmaceuticals?

A: The advantages of using natural dyes like turmeric extract in pharmaceuticals include safety, attractiveness, antioxidant properties, and sustainability. Natural dyes are generally considered safer than synthetic dyes, which can have a negative impact on health.

Q: How is turmeric rhizome extract extracted?

A: Turmeric rhizome extract is extracted using the method of percolation with 96% ethanol solvent. This method involves soaking the turmeric rhizomes in ethanol to release the active compounds, which are then collected and concentrated.

Q: What are the different concentrations of turmeric extract used in this study?

A: The different concentrations of turmeric extract used in this study are 1%, 1.5%, and 2%. These concentrations were chosen to determine the most preferred concentration for coloring vitamin C tablets.

Q: What are the evaluation criteria used to assess the quality of the vitamin C tablets?

A: The evaluation criteria used to assess the quality of the vitamin C tablets include violence, friability, destroyed time, uniformity of the content, determination of levels, dissolution, and assessment by 20 panelists regarding color.

Q: What are the results of the hedonic test?

A: The results of the hedonic test show that varying preference assessment, with F6 and F5 is considered "like" and "very like" by panelists. This indicates that the vitamin C tablets colored with turmeric extract are preferred by consumers.

Q: Can turmeric extract be used as a coloring agent in other pharmaceutical products?

A: Yes, turmeric extract can be used as a coloring agent in other pharmaceutical products. However, further research is needed to determine the optimal concentration and formulation for each product.

Q: What are the potential health benefits of using turmeric extract in pharmaceuticals?

A: The potential health benefits of using turmeric extract in pharmaceuticals include antioxidant properties, anti-inflammatory effects, and potential anti-cancer properties.

Q: Is turmeric extract safe for use in pharmaceuticals?

A: Yes, turmeric extract is generally considered safe for use in pharmaceuticals. However, further research is needed to determine the optimal concentration and formulation for each product.

Q: Can I use turmeric extract as a coloring agent in my own pharmaceutical products?

A: No, it is not recommended to use turmeric extract as a coloring agent in your own pharmaceutical products without proper training and expertise. Pharmaceutical products require strict quality control and regulatory compliance, and using turmeric extract without proper knowledge and experience can lead to adverse effects.

Q: Where can I find more information about using turmeric extract in pharmaceuticals?

A: You can find more information about using turmeric extract in pharmaceuticals by consulting scientific literature, regulatory agencies, and pharmaceutical industry experts.