The Importance of Monitoring and Assessment in Critical Illness Children

Oct 13, 2025 by windailys.com 60 views

The Relationship of Bacterial Infection Markers with Organ Dysfunction Based on Pelod-2 Scores in Critical Illness Children

Introduction

Critical illness in children is a life-threatening condition that requires immediate attention and proper management. One of the major complications of critical illness is organ dysfunction, which can lead to increased morbidity and mortality rates. Therefore, it is essential to have a reliable tool for assessing organ dysfunction in children. The Pediatric Logistics Dysfunction 2 (Pelod-2) Score is a widely used tool for determining the severity of organ dysfunction in pediatric patients. However, the relationship between bacterial infection markers and Pelod-2 scores in critical illness children is not well understood.

The Importance of Monitoring and Assessment in Critical Illness Children

Children who are treated in critical conditions often experience body homeostasis disorders, which can result in organ dysfunction and increase the risk of death. Therefore, appropriate monitoring and assessment are very important in handling this patient. The Pelod-2 Score is a valuable tool for medical personnel in determining the severity of the child's condition and planning the necessary medical measures. By analyzing the relationship between bacterial infection markers and Pelod-2 scores, we can get a better understanding of the clinical conditions of a critical illness patient.

Research Purposes

This study aims to determine the relationship between neutrophil, lymphocyte, neutrophil/lymphocyte, platelet, RDW, PCT, and CRP dysfunction ratios with measured organ dysfunction through Pelod-2 scores in pediatric patients who are in critical condition. The study will provide valuable insights into the clinical conditions of critical illness children and help medical professionals in making informed decisions.

Research Methods

In this study, the analytic method with a cross-sectional approach was applied to pediatric patients in critical illness aged over 1 month to 18 years. The research subjects were taken from the High Care Unit (HCU) and the Pediatric Intensive Care Unit (PICU) at Adam Malik Hospital, Medan, in the November 2020 period to February 2021. Assessment of Pelod-2 Scores and Laboratory Examination which included neutrophils, lymphocytes, neutrophils ratios /lymphocytes, platelets, RDW, PCT, and CRP are carried out within 24 hours after the patient is treated.

Research Result

Of the 52 subjects analyzed, the results show that the neutrophils, lymphocyte, neutrophil/lymphocyte, platelet, and RDW ratios which are measured in the first 24 hours have no correlation with Pelod-2 scores in critical illness children. Conversely, the value of PCT and CRP measured at the same time indicates a positive correlation with Pelod-2-2 scores. For PCT, the value of R = 0.463 (p = 0.001) is obtained, while for CRP, the value of R = 0.320 (p = 0.021) against the Pelod-2 score.

Conclusion

The results showed that PCT and CRP had a significant positive correlation with Pelod-2 scores in critical illness children. Increasing the value of PCT and CRP is in line with an increase in Pelod-2 scores, which shows that these two markers can be used as an initial indicator in assessing the severity of organ dysfunction due to bacterial infections in children in critical conditions. This knowledge is not only valuable to medical professionals in clinical decision making, but also provides important insights for further research in the field of pediatrics.

Implications of the Study

The findings of this study have significant implications for the management of critical illness children. The use of PCT and CRP as markers for assessing organ dysfunction due to bacterial infections can help medical professionals in making informed decisions. Additionally, the study provides valuable insights for further research in the field of pediatrics, which can lead to the development of new diagnostic tools and treatments for critical illness children.

Limitations of the Study

This study has several limitations. The sample size is relatively small, and the study was conducted in a single hospital. Therefore, the results may not be generalizable to other populations. Additionally, the study only examined the relationship between PCT and CRP with Pelod-2 scores, and did not investigate other potential markers of organ dysfunction.

Future Directions

Future studies should aim to replicate the findings of this study and investigate the relationship between other markers of organ dysfunction and Pelod-2 scores. Additionally, studies should aim to develop new diagnostic tools and treatments for critical illness children, based on the insights gained from this study.

References

[List of references cited in the study]

Appendix

[List of appendices, including tables, figures, and additional data]

Abstract

This study aimed to determine the relationship between neutrophil, lymphocyte, neutrophil/lymphocyte, platelet, RDW, PCT, and CRP dysfunction ratios with measured organ dysfunction through Pelod-2 scores in pediatric patients who are in critical condition. The results showed that PCT and CRP had a significant positive correlation with Pelod-2 scores in critical illness children. The study provides valuable insights for further research in the field of pediatrics and has significant implications for the management of critical illness children.
Q&A: The Relationship of Bacterial Infection Markers with Organ Dysfunction Based on Pelod-2 Scores in Critical Illness Children

Q: What is the Pelod-2 Score and how is it used in assessing organ dysfunction in children?

A: The Pelod-2 Score is a widely used tool for determining the severity of organ dysfunction in pediatric patients. It is a scoring system that takes into account various physiological and laboratory parameters to assess the severity of organ dysfunction.

Q: What are the bacterial infection markers that were studied in this research?

A: The bacterial infection markers that were studied in this research include neutrophils, lymphocytes, neutrophil/lymphocyte ratios, platelets, Red Blood Cell Distribution Width (RDW), C-Reactive Protein (CRP), and Procalcitonin (PCT).

Q: What were the findings of the study regarding the relationship between bacterial infection markers and Pelod-2 scores?

A: The study found that PCT and CRP had a significant positive correlation with Pelod-2 scores in critical illness children. This means that as the value of PCT and CRP increases, the Pelod-2 score also increases, indicating a more severe level of organ dysfunction.

Q: What are the implications of this study for the management of critical illness children?

A: The findings of this study have significant implications for the management of critical illness children. The use of PCT and CRP as markers for assessing organ dysfunction due to bacterial infections can help medical professionals in making informed decisions.

Q: What are the limitations of this study?

A: This study has several limitations. The sample size is relatively small, and the study was conducted in a single hospital. Therefore, the results may not be generalizable to other populations.

Q: What are the future directions for research based on the findings of this study?

A: Future studies should aim to replicate the findings of this study and investigate the relationship between other markers of organ dysfunction and Pelod-2 scores. Additionally, studies should aim to develop new diagnostic tools and treatments for critical illness children, based on the insights gained from this study.

Q: How can the findings of this study be applied in clinical practice?

A: The findings of this study can be applied in clinical practice by using PCT and CRP as markers for assessing organ dysfunction due to bacterial infections. This can help medical professionals in making informed decisions and providing timely and effective treatment to critical illness children.

Q: What are the potential benefits of using PCT and CRP as markers for assessing organ dysfunction?

A: The potential benefits of using PCT and CRP as markers for assessing organ dysfunction include earlier detection of organ dysfunction, more accurate assessment of disease severity, and more effective treatment of critical illness children.

Q: What are the potential limitations of using PCT and CRP as markers for assessing organ dysfunction?

A: The potential limitations of using PCT and CRP as markers for assessing organ dysfunction include the need for further research to confirm the findings of this study, the potential for false positives or false negatives, and the need for careful interpretation of results.

Q: How can healthcare providers stay up-to-date with the latest research and developments in the field of pediatric critical care?

A: Healthcare providers can stay up-to-date with the latest research and developments in the field of pediatric critical care by attending conferences and workshops, reading scientific journals and publications, and participating in online forums and discussions.

Q: What are the potential future directions for research in the field of pediatric critical care?

A: The potential future directions for research in the field of pediatric critical care include the development of new diagnostic tools and treatments, the investigation of new biomarkers for assessing organ dysfunction, and the study of the effects of critical illness on long-term health outcomes.