The Importance of Mean Platelet Volume in Cardiovascular Events

Oct 13, 2025 by windailys.com 8 views

The Addition of Mean Platelet Volume Value in the GRACE Score as a Predictor of Major Cardiovascular Events During Treatment in Acute Coronary Syndrome Patients in H. Adam Malik Hospital Medan

Acute coronary syndrome (SKA) is a term used to describe the symptoms caused by acute myocardial infarction (IMA). In current medical practice, risk stratification on SKA is carried out using the Global Registry of Acute Coronary Events (GRACE) scores, which have been tested as predictors for cardiovascular events in SKA patients. However, laboratory variables that are calculated in this score are limited only on serum and troponin creatinine examinations. One other variable that has the potential to increase the predictive value is the mean platelet volume (MPV), which is an indicator of platelet size. The MPV is a crucial factor in determining the risk of cardiovascular events, and its inclusion in the GRACE score can significantly improve the predictive value of the score.

The Importance of Mean Platelet Volume in Cardiovascular Events

The MPV is a measure of the average size of platelets in the blood. Platelets play a crucial role in blood clotting, and an increase in MPV can indicate an increased risk of cardiovascular events. Studies have shown that patients with higher MPV values are at a higher risk of developing cardiovascular disease, including acute coronary syndrome. The inclusion of MPV in the GRACE score can provide a more accurate prediction of cardiovascular events, allowing healthcare providers to take proactive measures to prevent these events.

This research is an ambisant cohort research involving 219 SKA patients undergoing treatment at H. Adam Malik Hospital from November 2017 to November 2018. The study aimed to evaluate the role of adding MPV scores to the GRACE score in predicting major cardiovascular events (KKVM) during the treatment period. During the study, GRACE scores and MPV scores of each patient were counted, and they were observed during the hospital treatment period. Outputs monitored are the events of KKVM during the nursing period. The analysis was carried out to evaluate the role of adding MPV scores on GRACE scores in predicting KKVM events.

The results showed that the MPV score and GRACE score increased in patients who experienced KKVM compared to those who did not. The Under Curve (AUC) Area Analysis on the ROC curve shows a value of 0.786 (95% CI: 0.717-0.855, p <0.001) when the GRACE score is calculated independently. However, when the MPV value was added, AUC increased to 0.946 (95% CI: 0.912−0.980, p <0.001). This shows that the combination of MPV with a GRACE score can significantly increase predictive value.

Based on the results of the study, the addition of MPV scores to the GRACE score was proven to provide a higher predictive value in predicting KKVM events in SKA patients who were hospitalized. This study underlines the importance of including additional variables such as MPV in the risk evaluation of SKA patients, which can help the management and care of patients better. Thus, MPV monitoring needs to be considered as part of a more comprehensive clinical assessment to increase the outcome of SKA patients in hospitals.

The findings of this study have significant implications for the management of SKA patients. The inclusion of MPV in the GRACE score can provide a more accurate prediction of cardiovascular events, allowing healthcare providers to take proactive measures to prevent these events. The study highlights the importance of considering additional variables such as MPV in the risk evaluation of SKA patients. This can help healthcare providers to develop more effective treatment plans and improve patient outcomes.

While the study provides valuable insights into the role of MPV in predicting cardiovascular events, there are some limitations to consider. The study was conducted in a single hospital setting, which may limit the generalizability of the findings. Further studies are needed to confirm the results and to explore the role of MPV in other patient populations.

The findings of this study have significant implications for future research in the field of cardiovascular medicine. Further studies are needed to explore the role of MPV in predicting cardiovascular events, including the development of new biomarkers and the evaluation of the effectiveness of MPV-based risk stratification. The study highlights the importance of considering additional variables such as MPV in the risk evaluation of SKA patients, and future studies should aim to build on this finding.

In conclusion, the addition of MPV scores to the GRACE score was proven to provide a higher predictive value in predicting KKVM events in SKA patients who were hospitalized. The study underlines the importance of including additional variables such as MPV in the risk evaluation of SKA patients, which can help the management and care of patients better. Thus, MPV monitoring needs to be considered as part of a more comprehensive clinical assessment to increase the outcome of SKA patients in hospitals.
Frequently Asked Questions (FAQs) About the Addition of Mean Platelet Volume Value in the GRACE Score as a Predictor of Major Cardiovascular Events During Treatment in Acute Coronary Syndrome Patients in H. Adam Malik Hospital Medan

A: The GRACE score is a risk stratification tool used to predict the likelihood of cardiovascular events in patients with acute coronary syndrome (ACS). It takes into account various clinical and laboratory variables, including age, sex, medical history, and biomarker levels. The GRACE score is used to identify patients at high risk of cardiovascular events and to guide treatment decisions.

A: Mean platelet volume (MPV) is a measure of the average size of platelets in the blood. Platelets play a crucial role in blood clotting, and an increase in MPV can indicate an increased risk of cardiovascular events. Studies have shown that patients with higher MPV values are at a higher risk of developing cardiovascular disease, including acute coronary syndrome.

A: The addition of MPV to the GRACE score can significantly improve the predictive value of the score. The study found that the combination of MPV with a GRACE score can increase the area under the curve (AUC) from 0.786 to 0.946, indicating a more accurate prediction of cardiovascular events.

A: The study highlights the importance of considering additional variables such as MPV in the risk evaluation of ACS patients. This can help healthcare providers to develop more effective treatment plans and improve patient outcomes. The inclusion of MPV in the GRACE score can provide a more accurate prediction of cardiovascular events, allowing healthcare providers to take proactive measures to prevent these events.

A: The study was conducted in a single hospital setting, which may limit the generalizability of the findings. Further studies are needed to confirm the results and to explore the role of MPV in other patient populations. Additionally, further research is needed to develop new biomarkers and to evaluate the effectiveness of MPV-based risk stratification.

A: The potential benefits of incorporating MPV into the GRACE score for ACS patients include:

Improved predictive value of the score
More accurate identification of high-risk patients
Development of more effective treatment plans
Improved patient outcomes

A: The potential challenges of incorporating MPV into the GRACE score for ACS patients include:

Limited availability of MPV data
Need for further research to confirm the results
Potential for increased complexity in risk stratification
Need for education and training for healthcare providers

A: The next steps for incorporating MPV into the GRACE score for ACS patients include:

Further research to confirm the results and to explore the role of MPV in other patient populations
Development of new biomarkers and evaluation of the effectiveness of MPV-based risk stratification
Education and training for healthcare providers on the use of MPV in risk stratification
Implementation of MPV-based risk stratification in clinical practice.