The Importance of Kidney Protection

Oct 13, 2025 by windailys.com 86 views

Test of Ethanol Extract Activity Herba Puguntano (Picria Fel-Terrae Merr.) Against the Paracetamol Paracetamol Paracetamol Kidney Parameters

Background

Paracetamol is one of the most widely used drugs as analgesics-antipyretic worldwide. This drug is easily obtained, even in many countries, paracetamol is available without a doctor's prescription. Although effective in reducing pain and fever, excessive paracetamol doses can cause serious damage to the kidneys. Therefore, it is important to find solutions that can protect the kidneys from this harmful effect. One possible way is to use medicinal plants that contain flavonoids, which are known to have protective properties against organs, including the kidneys. Herba Puguntano, or Picria Fel-Terrae Merr, is one of the plants that has flavonoids that can help overcome kidney damage due to paracetamol consumption.

The Importance of Kidney Protection

The kidneys play a vital role in our body, filtering waste and excess fluids from the blood. However, excessive paracetamol consumption can cause damage to the kidneys, leading to serious health problems. According to recent studies, paracetamol-induced kidney damage is a major concern worldwide. Therefore, it is essential to find effective solutions to protect the kidneys from this harm. One possible way is to use medicinal plants that contain flavonoids, which are known to have protective properties against organs, including the kidneys.

Research Purposes

This study aims to evaluate the activity of ethanol extract from Puguntano herbs on the parameters of kidney function in male mice that have been induced with paracetamol. The main objective of this study is to investigate the potential of Puguntano herbs in protecting the kidneys from paracetamol-induced damage.

Research Methods

Fifteen male mice are divided into five different groups. The first group is a normal group that does not receive treatment, while other groups are the treatment group given by paracetamol induction. The treatment group includes:

Groups that are only given food and drink.
Groups given catechins.
The group given a carboxy methyl cellulose (CMC) is 0.5%.
Groups given Ethanol extract of Puguntano Herbs with a dose of 250 mg/kg body weight (BB).
The group given by Puguntano herb's ethanol extract at a dose of 500 mg/kg BW.

For eight days, all groups received appropriate treatment. On the eighth day, after one hour of treatment, four groups induced were then given paracetamol at a dose of 1,350 mg/kg BW. After treatment, mice are sacrificed using chloroform to take blood samples to be tested for creatinine and serum urea levels. The research data were analyzed using the One-way Anova test and continued with the Post Hoc Tukey test to see the differences between groups.

Research Result

The results of the analysis using the ANOVA test showed that the administration of Puguntano herbal ethanol extract with a dose of 250 mg/kg BW and 500 mg/kg BW significantly reduced urea levels in serum compared to negative control groups that were only given CMC (p <0.05). However, the two doses do not show a significant difference in the creatinine levels of rat serum.

Conclusion

From the results of the study it can be concluded that ethanol extract from Puguntano herbs has the potential to be good for kidney health, especially at a dose of 250 mg/kg BW. These findings highlight the importance of further research related to the use of herbal extracts in protecting vital organs, especially the kidneys, from damage due to conventional treatment such as paracetamol. Given the side effects that may be caused by drugs, the use of herbal extracts as adjuvants in treatment can be a promising alternative to improve kidney health.

The Future of Herbal Medicine

With a deeper understanding of the benefits of Puguntano herbs, it is hoped that the community can be more aware of the importance of the use of safe and effective herbal medicines as a protector of body health. The use of herbal extracts as adjuvants in treatment can be a promising alternative to improve kidney health and reduce the risk of kidney damage. Further research is needed to fully understand the potential of Puguntano herbs in protecting the kidneys from paracetamol-induced damage.

Recommendations

Based on the findings of this study, the following recommendations are made:

Further research is needed to fully understand the potential of Puguntano herbs in protecting the kidneys from paracetamol-induced damage.
The use of herbal extracts as adjuvants in treatment can be a promising alternative to improve kidney health and reduce the risk of kidney damage.
The community should be more aware of the importance of the use of safe and effective herbal medicines as a protector of body health.

Limitations of the Study

This study has several limitations, including:

The study was conducted on male mice, and the results may not be applicable to humans.
The study only investigated the effect of Puguntano herbs on kidney function, and the effects on other organs are not known.
The study only used a small sample size, and further research is needed to confirm the findings.

Future Directions

Future research should focus on:

Investigating the effects of Puguntano herbs on other organs, such as the liver and heart.
Conducting studies on humans to confirm the findings of this study.
Investigating the potential of Puguntano herbs in protecting against other types of kidney damage, such as diabetic nephropathy.

Conclusion

In conclusion, this study provides evidence that ethanol extract from Puguntano herbs has the potential to be good for kidney health, especially at a dose of 250 mg/kg BW. The use of herbal extracts as adjuvants in treatment can be a promising alternative to improve kidney health and reduce the risk of kidney damage. Further research is needed to fully understand the potential of Puguntano herbs in protecting the kidneys from paracetamol-induced damage.
Q&A: Test of Ethanol Extract Activity Herba Puguntano (Picria Fel-Terrae Merr.) Against the Paracetamol Paracetamol Paracetamol Kidney Parameters

Q: What is the main objective of this study?

A: The main objective of this study is to investigate the potential of Puguntano herbs in protecting the kidneys from paracetamol-induced damage.

Q: What is paracetamol-induced kidney damage?

A: Paracetamol-induced kidney damage is a condition where the kidneys are damaged due to excessive consumption of paracetamol. This can lead to serious health problems, including kidney failure.

Q: What is Herba Puguntano?

A: Herba Puguntano, also known as Picria Fel-Terrae Merr, is a plant that contains flavonoids, which are known to have protective properties against organs, including the kidneys.

Q: What is the significance of this study?

A: This study is significant because it provides evidence that ethanol extract from Puguntano herbs has the potential to be good for kidney health, especially at a dose of 250 mg/kg BW. This finding highlights the importance of further research related to the use of herbal extracts in protecting vital organs, especially the kidneys, from damage due to conventional treatment such as paracetamol.

Q: What are the limitations of this study?

A: This study has several limitations, including:

The study was conducted on male mice, and the results may not be applicable to humans.
The study only investigated the effect of Puguntano herbs on kidney function, and the effects on other organs are not known.
The study only used a small sample size, and further research is needed to confirm the findings.

Q: What are the potential applications of this study?

A: The potential applications of this study include:

The use of herbal extracts as adjuvants in treatment to improve kidney health and reduce the risk of kidney damage.
The development of new treatments for paracetamol-induced kidney damage.
The investigation of the potential of Puguntano herbs in protecting against other types of kidney damage, such as diabetic nephropathy.

Q: What are the next steps in this research?

A: The next steps in this research include:

Conducting further studies on humans to confirm the findings of this study.
Investigating the effects of Puguntano herbs on other organs, such as the liver and heart.
Investigating the potential of Puguntano herbs in protecting against other types of kidney damage, such as diabetic nephropathy.

Q: What are the implications of this study for public health?

A: The implications of this study for public health are significant. The use of herbal extracts as adjuvants in treatment can be a promising alternative to improve kidney health and reduce the risk of kidney damage. This can lead to a reduction in the incidence of kidney disease and related complications.

Q: What are the potential risks associated with the use of Puguntano herbs?

A: The potential risks associated with the use of Puguntano herbs include:

Allergic reactions.
Interactions with other medications.
Unknown effects on other organs.

Q: How can readers learn more about this study?

A: Readers can learn more about this study by:

Contacting the researchers directly.
Reading the full text of the study.
Searching for related studies and articles.

Q: What are the future directions for this research?

A: The future directions for this research include:

Investigating the effects of Puguntano herbs on other organs, such as the liver and heart.
Conducting studies on humans to confirm the findings of this study.
Investigating the potential of Puguntano herbs in protecting against other types of kidney damage, such as diabetic nephropathy.