Proportion of Histopathology Subtype Based on Location

Oct 13, 2025 by windailys.com 76 views

Proportion of Ameloblastoma Histopathology Subtype Based on Location, Tumor Size, and Radiology Overview at Adam Malik Hajj Center General Hospital in 2012-2016

Introduction

Ameloblastoma is a type of tumor that originates from the odontogenic epithelium and is one of the most common types of odontogenic epithelial tumors. Despite its slow growth, this tumor is locally invasive and can appear in various locations and different radiological sizes and features. Although there is a wealth of information available on its clinical and histopathological characteristics, research that explores the proportion of ameloblastoma histopathology subtype based on location, tumor size, and specific radiological description at the Adam Malik Hajj Center General Hospital in Medan is still very limited.

Background

Ameloblastoma is a type of tumor that is characterized by its slow growth and local invasiveness. It can appear in various locations, including the mandible and maxilla, and can have different radiological sizes and features. Despite its relatively slow growth, ameloblastoma is a significant health concern due to its potential to cause local destruction and its potential for recurrence. The histopathological characteristics of ameloblastoma are also of great interest, as they can provide important insights into the behavior and prognosis of this tumor.

Objective

The objective of this study is to identify whether there are dominant histopathology subtypes based on location, tumor size, and certain radiological features in Ameloblastoma patients treated at Adam Malik Haji Hospital Medan. This study aims to provide a comprehensive understanding of the proportion of ameloblastoma histopathology subtype based on location, tumor size, and radiology overview at Adam Malik Hajj Center General Hospital in Medan.

Materials and Methods

This research is descriptive with a latitude cutting approach. The research sample included medical record data and slides or paraffin blocks from patients diagnosed with ameloblastoma at Adam Malik Hospital Medan. Each ameloblastoma slide was determined the histopathological subtype and was associated with location data, tumor size, and radiological features contained in the patient's medical record.

Results

From the data collected from 25 samples, this study shows several important findings.

Proportion of Histopathology Subtype Based on Location

In the mandibular, the most commonly found histopathology subtype is follicular (68.42%), followed by Pleksform (26.32%) and Extraosseus (5.26%).
In the maxilla, the proportion obtained is Plexiform (57.14%), follicular (28.57%), and unique (14.29%).

Proportion of Histopathology Subtype Based on Tumor Size

For tumor sizes less than 5 cm, Plexiforms (16%), follicular (8%), extraosseus (4%) are found, and unique (4%).
For the size of the tumor between 5-10 cm, the follicular subtype occupies the dominant position (36%), with a plexiform (16%).
Whereas in tumors with sizes of more than 10 cm, follicular recorded (12%) and plexiforms (4%).

Proportion of histopathology subtypes based on radiological features

In a multilocular picture, follicular subtypes are found as much as 44%, 24%plexiform, and 4%extraosseus.
In the unilocular features, both follicular and plexiforms each recorded 12%, while unique 4%.

Conclusions

Based on research conducted, it can be concluded that ameloblastoma is most commonly found in the mandibular, with the dominant histopathological subtype is follicular. The most common tumor size is between 5-10 cm, with follicular subtypes and multilocular radiology features also show dominance in follicular subtypes. These findings provide important insights for medical practitioners in diagnosing and caring for patients with ameloblastoma, as well as being the basis for further research on this tumor.

Implications

This study provides a comprehensive understanding of the proportion of ameloblastoma histopathology subtype based on location, tumor size, and radiology overview at Adam Malik Hajj Center General Hospital in Medan. The findings of this study can be used to improve the diagnosis and treatment of patients with ameloblastoma, and can also provide a basis for further research on this tumor. Additionally, this study highlights the importance of considering the histopathological characteristics of ameloblastoma in the diagnosis and treatment of this tumor.

Limitations

This study has several limitations. The sample size of this study is relatively small, and the study was conducted at a single hospital. Therefore, the findings of this study may not be generalizable to other populations or settings. Additionally, the study only considered the histopathological characteristics of ameloblastoma, and did not consider other factors that may be relevant to the diagnosis and treatment of this tumor.

Future Directions

Future studies should aim to replicate the findings of this study and to explore the histopathological characteristics of ameloblastoma in other populations and settings. Additionally, future studies should consider other factors that may be relevant to the diagnosis and treatment of this tumor, such as genetic and molecular characteristics. By considering these factors, future studies can provide a more comprehensive understanding of the biology and behavior of ameloblastoma, and can inform the development of more effective diagnostic and treatment strategies for this tumor.
Frequently Asked Questions (FAQs) about Ameloblastoma

Q: What is Ameloblastoma?

A: Ameloblastoma is a type of tumor that originates from the odontogenic epithelium and is one of the most common types of odontogenic epithelial tumors. Despite its slow growth, this tumor is locally invasive and can appear in various locations and different radiological sizes and features.

Q: What are the common locations where Ameloblastoma occurs?

A: Ameloblastoma can occur in various locations, including the mandible and maxilla. According to our study, the most common location is the mandibular, with the dominant histopathological subtype being follicular.

Q: What are the common histopathological subtypes of Ameloblastoma?

A: The common histopathological subtypes of Ameloblastoma include follicular, plexiform, and extraosseus. Our study found that the most common histopathological subtype is follicular, followed by plexiform and extraosseus.

Q: What are the common radiological features of Ameloblastoma?

A: The common radiological features of Ameloblastoma include multilocular and unilocular pictures. Our study found that the multilocular picture is more common, with follicular subtypes being found as much as 44%.

Q: What is the significance of tumor size in Ameloblastoma?

A: Tumor size is an important factor in the diagnosis and treatment of Ameloblastoma. Our study found that the most common tumor size is between 5-10 cm, with follicular subtypes occupying the dominant position.

Q: What are the implications of this study for medical practitioners?

A: This study provides important insights for medical practitioners in diagnosing and caring for patients with Ameloblastoma. The findings of this study can be used to improve the diagnosis and treatment of patients with Ameloblastoma, and can also provide a basis for further research on this tumor.

Q: What are the limitations of this study?

A: This study has several limitations, including a relatively small sample size and a single hospital setting. Therefore, the findings of this study may not be generalizable to other populations or settings.

Q: What are the future directions for research on Ameloblastoma?

A: Future studies should aim to replicate the findings of this study and to explore the histopathological characteristics of Ameloblastoma in other populations and settings. Additionally, future studies should consider other factors that may be relevant to the diagnosis and treatment of this tumor, such as genetic and molecular characteristics.

Q: What can patients with Ameloblastoma expect from this study?

A: Patients with Ameloblastoma can expect a more comprehensive understanding of the biology and behavior of this tumor. The findings of this study can be used to improve the diagnosis and treatment of patients with Ameloblastoma, and can also provide a basis for further research on this tumor.

Q: How can patients with Ameloblastoma get involved in research on this tumor?

A: Patients with Ameloblastoma can get involved in research on this tumor by participating in clinical trials or by providing tissue samples for research purposes. Additionally, patients can also participate in online forums or support groups to connect with other patients and to stay informed about the latest research on Ameloblastoma.