Prevention and treatment strategies

Oct 13, 2025 by windailys.com 84 views

Introduction

Mandibular asymmetry is a complex and multifactorial condition that can be influenced by various aspects such as individual characteristics, time emergence, muscle compensation, and facial development. In this context, genetic factors play an important role in influencing fluctuating asymmetry expressions. This reflects how the body's homeostasis adapts to the physical environment and genetic structures associated with complex polygenic properties. This study focused on the existence of BMP-2 polymorphism, with RS235768 number, which allegedly acts as a signal molecule in the growth of the mandibular condition. Polymorphism identification is expected to provide a clearer picture of the clinical pathway that leads to the mandibular asymmetry.

Background

Mandibular asymmetry is a common condition that affects millions of people worldwide. It can be caused by various factors, including genetic, environmental, and hormonal influences. The condition can lead to various complications, such as malocclusion, facial pain, and decreased self-esteem. In recent years, there has been a growing interest in the role of genetic factors in the development of mandibular asymmetry. This study aims to investigate the relationship between BMP-2 polymorphism and mandibular asymmetry.

Methodology

This study is a descriptive analytic study that involves 60 mandibular asymmetry subjects who receive treatment at USU RSGM between March and November 2019. Subject criteria are determined to use the lemos method based on panoramic radiographic analysis. The research process includes DNA isolation from blood samples, which are then followed by genomic examination in the Integrated Laboratory of the USU Faculty of Medicine.

Results

The results showed a variety of polymorphism BMP-2 RS235768 in the mandibular asymmetry subject. There are three variations of sequences identified:

Sequence AT (153bp + 200bp): This sequence has a frequency of 23.33% (n = 14).
Sequence AA (353bp): This sequence is not found at all (0%, n = 0).
Sequence TT (250bp + 153bp): This sequence has a frequency of 76.67% (n = 46).

Thus, it can be concluded that the BMP-2 RS235768 polymorphism has a significant relationship with malocclusion associated with mandibular asymmetry.

Discussion

In-depth analysis of this result shows the importance of BMP-2 polymorphism as a factor that contributes to the development of mandibular asymmetry. Different sequence variations can provide an overview of individual vulnerability to this condition. This discovery has great clinical implications, given the understanding of genetic factors involved can help in the diagnosis and therapy planning for patients with mandibular asymmetry problems.

Furthermore, this research opens opportunities for further exploration of the interaction between genetic and environmental factors in facial development. This is important for the development of more effective prevention and treatment strategies, which can improve the quality of life of patients with asymmetry maloclicution. Further and in-depth research on other genetic polymorphisms as well as the factors that affect the mandibular asymmetry is expected to enrich our understanding of this condition.

Conclusion

In conclusion, this study provides evidence of the relationship between BMP-2 polymorphism and mandibular asymmetry. The results show that the BMP-2 RS235768 polymorphism has a significant relationship with malocclusion associated with mandibular asymmetry. This discovery has great clinical implications and opens opportunities for further research on the interaction between genetic and environmental factors in facial development.

Recommendations

Based on the results of this study, the following recommendations are made:

Further research: Further research is needed to investigate the relationship between other genetic polymorphisms and mandibular asymmetry.
Clinical application: The understanding of genetic factors involved in mandibular asymmetry can help in the diagnosis and therapy planning for patients with mandibular asymmetry problems.
Prevention and treatment strategies: The development of more effective prevention and treatment strategies is needed to improve the quality of life of patients with asymmetry maloclicution.

Limitations

This study has several limitations, including:

Small sample size: The sample size of this study is relatively small, which may limit the generalizability of the results.
Limited scope: This study only investigates the relationship between BMP-2 polymorphism and mandibular asymmetry, and does not explore other factors that may contribute to the condition.

Future Directions

Q: What is mandibular asymmetry?

A: Mandibular asymmetry is a complex and multifactorial condition that can be influenced by various aspects such as individual characteristics, time emergence, muscle compensation, and facial development.

Q: What is the role of genetic factors in mandibular asymmetry?

A: Genetic factors play an important role in influencing fluctuating asymmetry expressions, which reflects how the body's homeostasis adapts to the physical environment and genetic structures associated with complex polygenic properties.

Q: What is BMP-2 polymorphism?

A: BMP-2 (Bone Morphogenetic Protein-2) is a signal molecule that plays a crucial role in the growth and development of the mandible. Polymorphism refers to the existence of different forms of a gene or protein, which can affect the function and expression of the gene.

Q: What is the significance of the RS235768 polymorphism?

A: The RS235768 polymorphism is a specific variation of the BMP-2 gene that has been associated with mandibular asymmetry. This study found that the RS235768 polymorphism has a significant relationship with malocclusion associated with mandibular asymmetry.

Q: What are the clinical implications of this discovery?

A: The understanding of genetic factors involved in mandibular asymmetry can help in the diagnosis and therapy planning for patients with mandibular asymmetry problems. This discovery has great clinical implications and opens opportunities for further research on the interaction between genetic and environmental factors in facial development.

Q: What are the limitations of this study?

A: This study has several limitations, including a small sample size and limited scope. Further research is needed to investigate the relationship between other genetic polymorphisms and mandibular asymmetry.

Q: What are the future directions for research?

A: This study opens opportunities for further research on the interaction between genetic and environmental factors in facial development. Future studies can investigate the relationship between other genetic polymorphisms and mandibular asymmetry, as well as explore the clinical implications of this discovery.

Q: How can this research benefit patients with mandibular asymmetry?

A: This research can help in the development of more effective prevention and treatment strategies for patients with mandibular asymmetry. Understanding the genetic factors involved in mandibular asymmetry can help in the diagnosis and therapy planning for patients with this condition.

Q: What are the potential applications of this research?

A: This research has potential applications in the fields of orthodontics, oral surgery, and genetic medicine. Understanding the genetic factors involved in mandibular asymmetry can help in the development of more effective treatments for this condition.

Q: How can I get involved in this research?

A: If you are interested in getting involved in this research, you can contact the researchers directly or look for opportunities to participate in clinical trials or studies related to mandibular asymmetry.