Phyllodes tumors are not derived from existing fibroadenomas

Oct 13, 2025 by windailys.com 68 views

Comparison of Histochemical Proliferation Values of Argyrophilic Nucleolar Organizing Regions (AGNORS) on Benign Breast Phyllodes Tumors, Borderline, and Malignant

Background Phyllodes tumors are a rare type of biphasic breast tumor, consisting of two main components: neoplastic stroma cells and glands coated with epithelium. Despite their rarity, phyllodes tumors have distinct characteristics that set them apart from other breast tumors. The stroma element in phyllodes tumors is more cellular and larger in proportion compared to other tumors. Phyllodes tumors are not derived from existing fibroadenomas, unlike fibroadenomas, which are more common. The characteristics of malignancy that need to be watched out for in phyllodes tumors include increased cellularity of stroma, anaplasia, high mitotic activity, rapid growth of tumor size, and infiltrative edges. Phyllodes tumors are relatively rare, accounting for less than 1% of total breast neoplasms, with an incidence of around 0.3-0.5%. Most often, this tumor occurs at the age of 30 to 40 years.

Research Purposes This study aims to measure and compare the expression of Agnor histochemicals in the benign, borderline, and malignant phyllodes tumor. With this analysis, it is hoped that a better understanding of the difference in the characteristics of cellular proliferation in each tumor category can be achieved. The ultimate goal is to provide valuable insights into the diagnosis and prognosis of breast tumors.

Materials and Methods This study uses a latitude cutting study design involving 35 phyllodes tumor samples, consisting of 15 benign tumor samples, 8 borderline samples, and 12 malignant samples. The samples used in this study were in the form of paraffin blocks, which were then cut and colored with Agnor techniques. This process involves the calculation of Agnor points in 100 cell nuclei, and the results are averaged to get the mean value of Agnor (Magnor). Magnor values obtained are then analyzed using statistical software to determine the significance of differences between groups.

Results The analysis results show that there is a significant difference between the Magnor value of the three tumor groups. With the resulting P value of less than 0.001, further analysis shows that the value of the Magnor of Malignant Phyllodes tumors reaches an average of 5.37 (range 5.03-5.72), while the Phyllodes Borderline tumor has an average value of 2.63 (range 1.56-3.69), and the benign phyllodes tumor is at the lowest average value of 2.75 (range 1.69-3.8). All of these differences indicate strong significance (p <0.001).

Conclusions From the results of this study, it can be concluded that the value of Magnor in the malignant phyllodes tumor is the highest compared to the borderline and benign phyllodes tumors. This finding indicates that the Agnor value can be used as an important indicator in determining the level of malignancy of the phyllodes tumor. Thus, an understanding of the difference in the value of this proliferation can help in handling and managing breast tumors more effectively. Further research is still needed to explore the clinical implications of this result and to find other possibilities of biomarkers that can help in the diagnosis and prognosis of breast tumors.

Implications of the Study The results of this study have significant implications for the diagnosis and prognosis of breast tumors. The Agnor value can be used as a biomarker to determine the level of malignancy of phyllodes tumors. This can help in the early detection and treatment of malignant phyllodes tumors. Further research is needed to explore the clinical implications of this result and to find other possibilities of biomarkers that can help in the diagnosis and prognosis of breast tumors.

Limitations of the Study This study has several limitations. The sample size is relatively small, which may limit the generalizability of the results. The study only includes phyllodes tumors, and the results may not be applicable to other types of breast tumors. Further research is needed to confirm the findings of this study and to explore the clinical implications of the Agnor value.

Future Directions The results of this study have significant implications for the diagnosis and prognosis of breast tumors. Further research is needed to explore the clinical implications of this result and to find other possibilities of biomarkers that can help in the diagnosis and prognosis of breast tumors. The Agnor value can be used as a biomarker to determine the level of malignancy of phyllodes tumors, and this can help in the early detection and treatment of malignant phyllodes tumors.

Conclusion In conclusion, this study provides valuable insights into the diagnosis and prognosis of breast tumors. The Agnor value can be used as a biomarker to determine the level of malignancy of phyllodes tumors, and this can help in the early detection and treatment of malignant phyllodes tumors. Further research is needed to confirm the findings of this study and to explore the clinical implications of the Agnor value.
Q&A: Understanding the Comparison of Histochemical Proliferation Values of Argyrophilic Nucleolar Organizing Regions (AGNORS) on Benign Breast Phyllodes Tumors, Borderline, and Malignant

Q: What are Phyllodes Tumors? A: Phyllodes tumors are a rare type of biphasic breast tumor, consisting of two main components: neoplastic stroma cells and glands coated with epithelium.

Q: What are the characteristics of malignancy in Phyllodes Tumors? A: The characteristics of malignancy that need to be watched out for in Phyllodes Tumors include increased cellularity of stroma, anaplasia, high mitotic activity, rapid growth of tumor size, and infiltrative edges.

Q: What is the purpose of this study? A: This study aims to measure and compare the expression of Agnor histochemicals in the benign, borderline, and malignant Phyllodes tumor.

Q: What is the significance of the Agnor value in determining the level of malignancy of Phyllodes tumors? A: The Agnor value can be used as an important indicator in determining the level of malignancy of Phyllodes tumors.

Q: What are the implications of this study for the diagnosis and prognosis of breast tumors? A: The results of this study have significant implications for the diagnosis and prognosis of breast tumors. The Agnor value can be used as a biomarker to determine the level of malignancy of Phyllodes tumors.

Q: What are the limitations of this study? A: This study has several limitations, including a relatively small sample size and the study only includes Phyllodes tumors.

Q: What are the future directions for this research? A: Further research is needed to confirm the findings of this study and to explore the clinical implications of the Agnor value.

Q: Can the Agnor value be used as a biomarker for other types of breast tumors? A: The Agnor value may not be applicable to other types of breast tumors, and further research is needed to confirm its use as a biomarker.

Q: What are the potential benefits of using the Agnor value as a biomarker for Phyllodes tumors? A: The potential benefits of using the Agnor value as a biomarker for Phyllodes tumors include early detection and treatment of malignant Phyllodes tumors.

Q: What are the potential risks of using the Agnor value as a biomarker for Phyllodes tumors? A: The potential risks of using the Agnor value as a biomarker for Phyllodes tumors include false positives or false negatives, which can lead to unnecessary treatment or delayed diagnosis.

Q: How can the Agnor value be used in clinical practice? A: The Agnor value can be used in clinical practice as a biomarker to determine the level of malignancy of Phyllodes tumors. However, further research is needed to confirm its use and to develop guidelines for its use in clinical practice.

Q: What are the next steps for this research? A: Further research is needed to confirm the findings of this study and to explore the clinical implications of the Agnor value. This may include larger studies, longer follow-up periods, and the development of guidelines for the use of the Agnor value as a biomarker.