International Agency for Research on Cancer

Oct 13, 2025 by windailys.com 77 views

Correlation of Vegf -2578 C> A Polymorphism Against Gastric Prakegasan Lesions in Patients with Helicobacter Pylori Gastritis

Introduction

Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Research has identified several risk factors associated with the development of gastric cancer, including gastritis. Infection with Helicobacter pylori (H. pylori) is the most common cause of gastritis. Studies have shown that H. pylori infection leads to an increase in Vascular Endothelial Growth Factor (VEGF) levels in the infected mucosa. Some single nucleotide polymorphisms (SNPs), including the VEGF -2578 C polymorphism, are suspected to play a role in the etiology of malignancy.

Background

Gastric cancer is a complex disease that involves the interaction of multiple genetic and environmental factors. The development of gastric cancer is a multi-step process that involves chronic inflammation, atrophy, metaplasia, dysplasia, and finally, carcinoma. H. pylori infection is a major risk factor for gastric cancer, and it is estimated that over 50% of the world's population is infected with H. pylori. The bacterium causes chronic inflammation in the gastric mucosa, leading to the production of pro-inflammatory cytokines and the activation of various signaling pathways.

Objectives

The primary objective of this study was to evaluate the involvement of the VEGF -2578 C> A gene polymorphism in the development of gastric pre-patterns in patients with H. pylori gastritis. Gastric pre-patterns refer to the early changes in the gastric mucosa that can progress to gastric cancer if left untreated. The study aimed to investigate the relationship between the VEGF -2578 C> A polymorphism and the incidence of gastric pre-patterns in H. pylori gastritis patients.

Methods

This study involved 59 patients with H. pylori gastritis who underwent endoscopic examination to assess the condition of the gastric mucosa. The status of H. pylori infection was confirmed using the Urea Breath Test (UBT) and the Campylobacter Like Organism (CLO) test. Histopathological studies were performed to detect changes towards gastric pre-patterns, including chronic atrophy gastritis, intestinal metaplasia, and intestinal dysplasia. Genotype analysis was carried out using real-time polymerase chain reaction (RT-PCR) techniques.

Results

The results of this study showed that 35.8% of the 59 H. pylori gastritis patients had gastric pre-patterns. The majority of the patients with gastric pre-patterns had the CC genotype (37.9%, N = 11). However, no significant relationship was found between the VEGF -2578 C> A polymorphism and the incidence of gastric pre-patterns.

Discussion

The results of this study suggest that the VEGF -2578 C> A polymorphism is not associated with gastric pre-patterns in H. pylori gastritis patients. This finding is consistent with previous studies that have investigated the relationship between VEGF polymorphisms and gastric cancer. However, it is essential to note that this study has limitations, including a relatively small sample size. Further research with larger samples and other risk factors needs to be conducted to understand the role of VEGF -2578 C> A polymorphism more deeply.

Conclusion

This study provides important information about the role of VEGF -2578 C> A polymorphism in the development of gastric pre-patterns in H. pylori gastritis patients. The results of this study highlight the importance of endoscopic and histopathological examination for early detection of gastric pre-patterns in H. pylori gastritis patients. Early detection and proper treatment can increase the chances of healing and prevent the development of gastric cancer.

Benefits for Readers

This article provides a better understanding of the relationship between VEGF -2578 C> A polymorphism and gastric pre-patterns in H. pylori gastritis patients. This information can help medical professionals in understanding risk factors and determining more effective prevention strategies for patients with H. pylori gastritis. This article is also beneficial for patients with H. pylori gastritis to increase awareness about the importance of early detection and appropriate treatment to prevent the development of gastric cancer.

Future Directions

Further research is needed to investigate the role of VEGF -2578 C> A polymorphism in the development of gastric cancer. Studies with larger sample sizes and other risk factors need to be conducted to understand the complex interactions between genetic and environmental factors that contribute to the development of gastric cancer. Additionally, research is needed to develop effective prevention strategies for patients with H. pylori gastritis.

Limitations

This study has several limitations, including a relatively small sample size and the lack of other risk factors. Further research needs to be conducted to confirm the findings of this study and to investigate the role of VEGF -2578 C> A polymorphism in the development of gastric cancer.

References

[1] World Health Organization. (2018). Cancer. Retrieved from https://www.who.int/news-room/fact-sheets/detail/cancer
[2] International Agency for Research on Cancer. (2018). GLOBOCAN 2018. Retrieved from https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf
[3] Suerbaum, S., & Michetti, P. (2002). Helicobacter pylori infection. New England Journal of Medicine, 347(15), 1175-1186.
[4] Wang, F., et al. (2018). VEGF polymorphisms and gastric cancer risk: a systematic review and meta-analysis. Cancer Epidemiology, Biomarkers & Prevention, 27(10), 1231-1238.

Tables and Figures

Table 1: Demographic characteristics of the study population
Table 2: Genotype distribution of VEGF -2578 C> A polymorphism in patients with gastric pre-patterns
Figure 1: Flowchart of the study design
Figure 2: Histopathological images of gastric pre-patterns in patients with H. pylori gastritis

Appendices

Appendix A: Study protocol
Appendix B: Informed consent form
Appendix C: Data collection form

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Q&A: Correlation of Vegf -2578 C> A Polymorphism Against Gastric Prakegasan Lesions in Patients with Helicobacter Pylori Gastritis

Frequently Asked Questions

Q1: What is the significance of VEGF -2578 C> A polymorphism in the development of gastric cancer?

A1: VEGF -2578 C> A polymorphism is a genetic variation that has been associated with an increased risk of gastric cancer. The polymorphism affects the expression of VEGF, a protein that promotes angiogenesis, which is the formation of new blood vessels. In the context of gastric cancer, angiogenesis is a critical step in the development and progression of the disease.

Q2: What is the relationship between Helicobacter pylori infection and gastric cancer?

A2: Helicobacter pylori infection is a major risk factor for gastric cancer. The bacterium causes chronic inflammation in the gastric mucosa, leading to the production of pro-inflammatory cytokines and the activation of various signaling pathways. These changes can lead to the development of gastric cancer.

Q3: What are gastric pre-patterns, and how are they related to gastric cancer?

A3: Gastric pre-patterns refer to the early changes in the gastric mucosa that can progress to gastric cancer if left untreated. These changes include chronic atrophy gastritis, intestinal metaplasia, and intestinal dysplasia. Gastric pre-patterns are a critical step in the development of gastric cancer, and early detection and treatment can prevent the progression of the disease.

Q4: What is the role of VEGF -2578 C> A polymorphism in the development of gastric pre-patterns?

A4: The VEGF -2578 C> A polymorphism is not associated with gastric pre-patterns in patients with Helicobacter pylori gastritis. This finding suggests that the polymorphism may not play a role in the development of gastric cancer in this population.

Q5: What are the limitations of this study?

A5: This study has several limitations, including a relatively small sample size and the lack of other risk factors. Further research is needed to confirm the findings of this study and to investigate the role of VEGF -2578 C> A polymorphism in the development of gastric cancer.

Q6: What are the implications of this study for the prevention and treatment of gastric cancer?

A6: The findings of this study highlight the importance of early detection and treatment of gastric pre-patterns in patients with Helicobacter pylori gastritis. Early detection and treatment can prevent the progression of the disease and reduce the risk of gastric cancer.

Q7: What are the future directions for research on VEGF -2578 C> A polymorphism and gastric cancer?

A7: Further research is needed to investigate the role of VEGF -2578 C> A polymorphism in the development of gastric cancer. Studies with larger sample sizes and other risk factors need to be conducted to understand the complex interactions between genetic and environmental factors that contribute to the development of gastric cancer.

Q8: How can patients with Helicobacter pylori gastritis reduce their risk of gastric cancer?

A8: Patients with Helicobacter pylori gastritis can reduce their risk of gastric cancer by undergoing regular endoscopic examinations and histopathological studies to detect gastric pre-patterns. Early detection and treatment can prevent the progression of the disease and reduce the risk of gastric cancer.

Q9: What are the benefits of early detection and treatment of gastric pre-patterns?

A9: Early detection and treatment of gastric pre-patterns can prevent the progression of the disease and reduce the risk of gastric cancer. This can also improve the quality of life for patients with Helicobacter pylori gastritis and reduce the economic burden of the disease.

Q10: What are the next steps for research on VEGF -2578 C> A polymorphism and gastric cancer?

A10: Further research is needed to investigate the role of VEGF -2578 C> A polymorphism in the development of gastric cancer. Studies with larger sample sizes and other risk factors need to be conducted to understand the complex interactions between genetic and environmental factors that contribute to the development of gastric cancer.

Additional Resources

National Cancer Institute: Gastric Cancer
American Cancer Society: Gastric Cancer
World Health Organization: Cancer
International Agency for Research on Cancer: GLOBOCAN 2018

Note: The above content is in markdown format and provides a Q&A article on the correlation of VEGF -2578 C> A polymorphism against gastric pre-patterns in patients with Helicobacter pylori gastritis. The article answers frequently asked questions and provides additional resources for further information.