Correlation of Hematology Parameters with Serum Albumin and Cholesterol Values in Children with Nephrotic Syndrome

Oct 13, 2025 by windailys.com 149 views

Correlation of Hematology Parameters with Serum Albumin and Cholesterol Values in Children with Nephrotic Syndrome

Nephrotic syndrome (SN) is a common kidney disease found in children, characterized by proteinuria, hypoalbuminemia, edema, and hypercholesterolemia. Hematological parameter examination plays a crucial role in assessing the risk of infection and thromboembolism in patients with SN. This study aims to investigate the relationship between hematological parameters and serum albumin and cholesterol levels in children with nephrotic syndrome.

Research Purposes

The primary objective of this study is to assess the correlation between hematological parameters and serum albumin and cholesterol levels in children suffering from nephrotic syndrome. By understanding this relationship, healthcare professionals can develop more effective treatment strategies and prevent complications associated with this condition.

Research Methods

This study employed a cross-sectional approach at Adam Malik Haji Hospital, Medan, North Sumatra, from February 1, 2017 to December 1, 2017. A total of 65 children diagnosed with nephrotic syndrome were included in the study, with 49 meeting the inclusion criteria. The inclusion criteria consisted of children with SN relapse and resistant to steroids, without severe malnutrition, and with normal liver function. Pearson and Spearman correlation tests were used to analyze the relationship between hematological parameters and albumin and cholesterol levels.

Research Results

The study sample consisted of 31 boys and 18 girls, with 43% having good nutritional status and 6% in the malnutrition category. The analysis revealed that 37.7% of patients experienced SN relapse, while 63.26% were patients with SN resistant to steroids. The results showed that three types of hematological parameters were correlated with serum albumin levels:

Leukocytes (r = -0.29; p = 0.044)
Platelet (r = -0.23; p = 0.047)
Blood Sediment Rate (LED) (r = -0.29; p = 0.039)

In addition, platelets showed a positive correlation with cholesterol levels (r = 0.44; p = 0.001).

Conclusion

The study found a weak negative correlation between leukocytes, platelets, and blood sedimentation rates with albumin levels. Platelets also indicated a medium negative correlation with cholesterol levels. This hematological parameter examination can help healthcare professionals better understand the risk of infection and thromboembolism in patients with nephrotic syndrome.

Implications of the Study

Understanding the relationship between hematological parameters and serum albumin and cholesterol levels is crucial in managing nephrotic syndrome in children. This knowledge can aid healthcare professionals in formulating a more effective treatment strategy and preventing complications associated with this condition. By recognizing the correlation between hematological parameters and serum albumin and cholesterol levels, healthcare professionals can develop targeted interventions to mitigate the risk of infection and thromboembolism in patients with nephrotic syndrome.

Limitations of the Study

This study had several limitations, including the small sample size and the cross-sectional design. Future studies should aim to recruit a larger sample size and employ a longitudinal design to better understand the relationship between hematological parameters and serum albumin and cholesterol levels in children with nephrotic syndrome.

Future Directions

Future studies should focus on investigating the relationship between hematological parameters and serum albumin and cholesterol levels in children with nephrotic syndrome. Additionally, studies should aim to explore the impact of hematological parameter examination on treatment outcomes and patient outcomes in children with nephrotic syndrome.

Recommendations

Based on the findings of this study, healthcare professionals should consider incorporating hematological parameter examination into the management of nephrotic syndrome in children. This can help healthcare professionals better understand the risk of infection and thromboembolism in patients with nephrotic syndrome and develop targeted interventions to mitigate these risks.

Conclusion

In conclusion, this study found a weak negative correlation between leukocytes, platelets, and blood sedimentation rates with albumin levels, and a medium negative correlation between platelets and cholesterol levels. Understanding the relationship between hematological parameters and serum albumin and cholesterol levels is crucial in managing nephrotic syndrome in children. This knowledge can aid healthcare professionals in formulating a more effective treatment strategy and preventing complications associated with this condition.
Frequently Asked Questions (FAQs) about Correlation of Hematology Parameters with Serum Albumin and Cholesterol Values in Children with Nephrotic Syndrome

Q: What is nephrotic syndrome (SN)?

A: Nephrotic syndrome (SN) is a common kidney disease found in children, characterized by proteinuria, hypoalbuminemia, edema, and hypercholesterolemia.

Q: What is the purpose of hematological parameter examination in patients with nephrotic syndrome?

A: Hematological parameter examination plays a crucial role in assessing the risk of infection and thromboembolism in patients with nephrotic syndrome.

Q: What are the hematological parameters that were correlated with serum albumin levels in this study?

A: The study found that three types of hematological parameters were correlated with serum albumin levels:

Leukocytes (r = -0.29; p = 0.044)
Platelet (r = -0.23; p = 0.047)
Blood Sediment Rate (LED) (r = -0.29; p = 0.039)

Q: What is the relationship between platelets and cholesterol levels in patients with nephrotic syndrome?

A: The study found a positive correlation between platelets and cholesterol levels (r = 0.44; p = 0.001).

Q: What are the implications of this study for the management of nephrotic syndrome in children?

A: Understanding the relationship between hematological parameters and serum albumin and cholesterol levels is crucial in managing nephrotic syndrome in children. This knowledge can aid healthcare professionals in formulating a more effective treatment strategy and preventing complications associated with this condition.

Q: What are the limitations of this study?

A: This study had several limitations, including the small sample size and the cross-sectional design. Future studies should aim to recruit a larger sample size and employ a longitudinal design to better understand the relationship between hematological parameters and serum albumin and cholesterol levels in children with nephrotic syndrome.

Q: What are the future directions for research in this area?

A: Future studies should focus on investigating the relationship between hematological parameters and serum albumin and cholesterol levels in children with nephrotic syndrome. Additionally, studies should aim to explore the impact of hematological parameter examination on treatment outcomes and patient outcomes in children with nephrotic syndrome.

Q: What recommendations can be made based on the findings of this study?

A: Based on the findings of this study, healthcare professionals should consider incorporating hematological parameter examination into the management of nephrotic syndrome in children. This can help healthcare professionals better understand the risk of infection and thromboembolism in patients with nephrotic syndrome and develop targeted interventions to mitigate these risks.

Q: What are the potential benefits of incorporating hematological parameter examination into the management of nephrotic syndrome in children?

A: Incorporating hematological parameter examination into the management of nephrotic syndrome in children can help healthcare professionals develop a more effective treatment strategy and prevent complications associated with this condition. This can lead to improved patient outcomes and reduced healthcare costs.

Q: What are the potential challenges of incorporating hematological parameter examination into the management of nephrotic syndrome in children?

A: One potential challenge is the need for healthcare professionals to have access to hematological parameter examination equipment and expertise. Additionally, there may be a need for healthcare professionals to receive training on how to interpret hematological parameter results and incorporate them into patient care.

Q: What are the potential future applications of this research?

A: This research has the potential to inform the development of new treatments for nephrotic syndrome in children. Additionally, this research can inform the development of new diagnostic tools and biomarkers for nephrotic syndrome.