Clinical Study and Methodology

Oct 13, 2025 by windailys.com 72 views

Comparison of the Effectiveness of Sidaguri Extracts (Sida Rhombifolia L) and Meloksikam in the Assessment of WOMAC Scores in Osteoarthritis Patients

Introduction

Osteoarthritis (OA) is a degenerative joint disease that affects millions of people worldwide, causing significant pain and disability. The World Health Organization (WHO) estimates that the prevalence of OA will increase by 40% by 2040, making it a major public health concern. The assessment of WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) scores is a widely used measuring instrument to evaluate the effectiveness of therapy in OA patients. A lower WOMAC score after therapy indicates that the treatment is effective. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage OA pain, but they have several side effects and may not be suitable for all patients.

Traditional Medicine and Anti-Inflammatory Effects

Traditional medicine has been used for centuries to manage various health conditions, including OA. One of the traditional medicines that has gained attention in recent years is the extract of Sidaguri (Sida Rhombifolia L). This plant is known to have anti-inflammatory effects, which are essential in managing OA pain. The anti-inflammatory effects of Sidaguri extract are attributed to its ability to inhibit the production of inflammatory markers, such as Nitric Oxide (NO).

Clinical Study and Methodology

A clinical study was conducted in the Rheumatology Polyclinic General Hospital Adam Malik Medan from September to November 2017. The study involved 50 OA patients who were randomly assigned to two groups. The first group received a combination of Sidaguri and Meloksikam extracts, while the second group received Meloksikam and a placebo. The patients were evaluated using WOMAC scores and examination of liver and kidney function before receiving therapy. The therapy period lasted for one month, after which the WOMAC score assessment was carried out again.

Results and Analysis

The results of the data analysis showed that the total WOMAC score for the group that received a combination of Sidaguri and Meloksikam extracts was 7.2% (from the range of 3.12-17.7%), while the group that received Meloksikam and a placebo had a total WOMAC score of 36.4% (from the range of 22-71.8%) with a value of P = 0.0001. This figure indicates that treatment with Sidaguri extracts gives far better results compared to using only Meloksikam and a placebo.

Conclusion and Future Directions

From the results of this study, it can be concluded that Sidaguri extract (Sida Rhombifolia L) is more effective in reducing WOMAC scores in OA patients when compared to the use of Meloksikam and a placebo. This shows that Sidaguri extract can be an alternative to effective therapy choices for patients suffering from OA. The effectiveness of Sidaguri as an anti-inflammatory drug tested in this study needs to be further considered, mainly because it has a lower side effect potential compared to synthetic NSAIDs such as Meloksikam. In addition, the use of herbal medicines such as Sidaguri is also in accordance with global trends to more natural therapy and minimal side effects.

This research opens opportunities for further research to explore the mechanism of work and optimal doses of Sidaguri extract, as well as possible use in combination with other therapy for more effective OA management. Given the prevalence of OA that continues to increase, this kind of approach is very important to improve the quality of life of patients.

Implications and Future Research Directions

The findings of this study have several implications for the management of OA. Firstly, the use of Sidaguri extract as an alternative to synthetic NSAIDs such as Meloksikam may reduce the risk of side effects associated with long-term use of these medications. Secondly, the use of herbal medicines such as Sidaguri may be more acceptable to patients who prefer natural therapy. Finally, the combination of Sidaguri extract with other therapy may provide more effective OA management.

Future research directions include:

Exploring the mechanism of work of Sidaguri extract in reducing WOMAC scores in OA patients
Determining the optimal doses of Sidaguri extract for effective OA management
Investigating the use of Sidaguri extract in combination with other therapy for more effective OA management
Conducting larger-scale studies to confirm the findings of this study

Limitations and Future Directions

This study has several limitations, including the small sample size and the short duration of the therapy period. Future studies should aim to recruit larger sample sizes and conduct longer-term therapy periods to confirm the findings of this study. Additionally, further research is needed to explore the mechanism of work of Sidaguri extract and to determine the optimal doses of Sidaguri extract for effective OA management.

Conclusion

In conclusion, this study provides evidence that Sidaguri extract (Sida Rhombifolia L) is more effective in reducing WOMAC scores in OA patients when compared to the use of Meloksikam and a placebo. This study highlights the potential of traditional medicine in managing OA and provides a new direction for OA management. Further research is needed to confirm the findings of this study and to explore the mechanism of work and optimal doses of Sidaguri extract.
Q&A: Sidaguri Extract and Osteoarthritis Management

Introduction

In our previous article, we discussed the effectiveness of Sidaguri extract (Sida Rhombifolia L) in reducing WOMAC scores in osteoarthritis (OA) patients. This traditional medicine has gained attention in recent years due to its anti-inflammatory effects and potential as an alternative to synthetic non-steroidal anti-inflammatory drugs (NSAIDs). In this Q&A article, we will address some of the most frequently asked questions about Sidaguri extract and its use in OA management.

Q: What is Sidaguri extract and how does it work?

A: Sidaguri extract is a traditional medicine derived from the Sida Rhombifolia L plant. It has been used for centuries to manage various health conditions, including OA. The anti-inflammatory effects of Sidaguri extract are attributed to its ability to inhibit the production of inflammatory markers, such as Nitric Oxide (NO).

Q: How effective is Sidaguri extract in reducing WOMAC scores in OA patients?

A: The results of our clinical study showed that Sidaguri extract is more effective in reducing WOMAC scores in OA patients when compared to the use of Meloksikam and a placebo. The total WOMAC score for the group that received a combination of Sidaguri and Meloksikam extracts was 7.2% (from the range of 3.12-17.7%), while the group that received Meloksikam and a placebo had a total WOMAC score of 36.4% (from the range of 22-71.8%) with a value of P = 0.0001.

Q: What are the potential benefits of using Sidaguri extract in OA management?

A: The use of Sidaguri extract in OA management may have several benefits, including:

Reduced risk of side effects associated with long-term use of synthetic NSAIDs
More acceptable therapy option for patients who prefer natural therapy
Potential for combination with other therapy for more effective OA management

Q: What are the potential limitations of using Sidaguri extract in OA management?

A: The use of Sidaguri extract in OA management may have several limitations, including:

Limited availability of high-quality Sidaguri extract
Limited understanding of the mechanism of work of Sidaguri extract
Potential for interactions with other medications

Q: How can I obtain Sidaguri extract and use it in OA management?

A: Sidaguri extract can be obtained from various sources, including traditional medicine shops and online retailers. However, it is essential to consult with a healthcare professional before using Sidaguri extract in OA management. They can help you determine the optimal dosage and ensure that you are using the extract safely and effectively.

Q: What are the potential interactions between Sidaguri extract and other medications?

A: The potential interactions between Sidaguri extract and other medications are not well understood. However, it is essential to consult with a healthcare professional before using Sidaguri extract in combination with other medications. They can help you determine the potential risks and benefits of using Sidaguri extract in combination with other medications.

Q: Can I use Sidaguri extract in combination with other therapy for OA management?

A: Yes, Sidaguri extract can be used in combination with other therapy for OA management. However, it is essential to consult with a healthcare professional before using Sidaguri extract in combination with other medications. They can help you determine the optimal dosage and ensure that you are using the extract safely and effectively.

Conclusion

In conclusion, Sidaguri extract (Sida Rhombifolia L) is a traditional medicine that has gained attention in recent years due to its anti-inflammatory effects and potential as an alternative to synthetic NSAIDs. While the use of Sidaguri extract in OA management may have several benefits, it is essential to consult with a healthcare professional before using the extract. They can help you determine the optimal dosage and ensure that you are using the extract safely and effectively.